Endocrine Abstracts

The ‘canonical’ Wnt/β-catenin pathway plays an important role in the development and patterning of bone. Dkk1 (Dickkopf1) and sclerostin are competitive soluble inhibitors of this pathway. Serum sclerostin is decreased in patients with primary hyperparathyroidism (PHPT) compared to the healthy subjects and hypoparathyroid (HypoPT) patients. No data are currently available on Dkk1 serum level in PHPT.We evaluated serum Dkk1 and sclerostin l...

Primary hyperparathyroidism (PHPT) is a frequent cause of secondary osteoporosis, but its role about the fracture is still controversial. We evaluated 157 consecutive postmenopausal patients with PHPT compared with two control subjects (C), each one matched for age and month-since-menopause (MSM). We measured ionized calcium (Ca2+), parathyroid hormone (PTH), 25-OH-vitamin D (25-OH vit D), osteocalcin (OC), bone alkaline phosphatase (B-ALP) and serum and urinary cro...